基本信息:
- 专利标题： DERIVATIVES OF KORORMICIN USEFUL AS ANTIBIOTICS
- 申请号：US15500006 申请日：2016-04-22
- 公开(公告)号：US20180064680A1 公开(公告)日：2018-03-08
- 发明人： Pavel Dibrov , Elena Dibrov , Grant Pierce
- 申请人： Pavel Dibrov , Elena Dibrov , Grant Pierce
- 国际申请： PCT/CA2016/050470 WO 20160422
- 主分类号： A61K31/341
- IPC分类号： A61K31/341 ; A61K31/365 ; A61K31/16 ; C07D309/30 ; C07F9/655
摘要：
An antibiotic compound is of formula (I): R1-R3, R5 and R6 are independently selected from H, alkyl group, substituted alkyl group, halogen, OH, NH2, or SH; R4 is H, alkyl group or substituted alkyl group. X1-X2 are independently selected from O, S, NH, H, alkyl, halogen, OH, SH, or NH2 Y is an acyclic hydrocarbon chain having 4 to 20 carbon atoms or a substituted acyclic hydrocarbon chain having 4 to 20 carbon atoms, but does not include an oxygen atom. Z is CH3 or any neutral or positively charged group. The compound can also be a salt or stereoisomer of formula (I). The compounds are useful in treating bacterial diseases.
公开/授权文献:
- US10166213B2 Derivatives of korormicin useful as antibiotics 公开/授权日：2019-01-01
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/34 | ...有仅以1个氧作为环杂原子的五元环的，例如异山梨醇 |
| --------------A61K31/341 | ....未与另一环稠合的，例如呋喃硝胺、速尿、丁呋心安、毒蕈碱 |