基本信息:
- 专利标题： INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
- 申请号：US15545891 申请日：2016-02-08
- 公开(公告)号：US20180016263A1 公开(公告)日：2018-01-18
- 发明人： Alexander Pasternak , Jessica Frie , Shuzhi Dong , Takao Suzuki , Shouning Xu
- 申请人： Alexander PASTERNAK , Jessica FRIE , Shuzhi DONG , Takao SUZUKI , Shouning XU , Merck Sharp & Dohme Corp.
- 优先权： CNPCT/CN2015/072865 20150212
- 国际申请： PCT/US16/16918 WO 20160208
- 主分类号： C07D405/14
- IPC分类号： C07D405/14 ; A61K31/496 ; C07D413/14
摘要：
The present invention provides compounds of Formula (I); and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
公开/授权文献:
- US10160751B2 Inhibitors of the renal outer medullary potassium channel 公开/授权日：2018-12-25
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D405/00 | 杂环化合物，含有1个或多个以氧原子作为仅有的杂环原子的环，且含有1个或多个以氮原子作为仅有的杂环原子的环 |
| --------C07D405/14 | .含3个或更多个杂环 |