发明申请
US20170320813A1 METHODS OF MANUFACTURING TREPROSTINIL AND TREPROSTINIL DERIVATIVE PRODRUGS
审中-公开
基本信息:
- 专利标题： METHODS OF MANUFACTURING TREPROSTINIL AND TREPROSTINIL DERIVATIVE PRODRUGS
- 申请号：US15527811 申请日：2015-11-18
- 公开(公告)号：US20170320813A1 公开(公告)日：2017-11-09
- 发明人： Vladimir Malinin , Walter Perkins , Franziska Leifer , Donna M. Konicek , Zhili Li , Adam Plaunt
- 申请人： Insmed Incorporated
- 国际申请： PCT/US15/61427 WO 20151118
- 主分类号： C07C231/02
- IPC分类号： C07C231/02 ; C07C67/08 ; C07C2601/18 ; C07C2602/24
摘要：
Methods for making prodrugs of trepreostinil and treprostinil derivatives are provided. Specifically, methods are provided herein for producing prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide). The linkage, in one embodiment, is via an amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. The compounds provided herein can be used to treat pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C231/00 | 羧酸酰胺的制备 |
| --------C07C231/02 | .通过与氨或胺反应从羧酸或从它们的酯、酐或卤化物来制备 |