基本信息:
- 专利标题： THERAPEUTIC COMPOUNDS AND USES THEREOF
- 申请号：US15482581 申请日：2017-04-07
- 公开(公告)号：US20170312292A1 公开(公告)日：2017-11-02
- 发明人： Anthony F. Romero , Steven R. Magnuson , Richard Pastor , Vickie Hsiao-Wei Tsui , Jeremy Murray , Terry Crawford , Daniel J. Burdick , Brian K. Albrecht , Alexandre Cote , Alexander M. Taylor , Christopher G. Nasveschuck , Yves LeBlanc , Michael Charles Hewitt , Kwong Wah Lai , Kevin Chen
- 申请人： GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
- 优先权： CNPCT/CN2014/088315 20141010
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D403/04 ; C07D243/24 ; A61K31/5513 ; C07D243/12 ; C07D223/16 ; C07D403/14 ; C07D267/14
摘要：
The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
公开/授权文献:
- US10206931B2 Therapeutic compounds and uses thereof 公开/授权日：2019-02-19
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/55 | ...有七元环的，例如氮卓斯汀、戊四唑 |