发明申请
US20170304305A1 QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF
审中-公开
基本信息:
- 专利标题： QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF
- 申请号：US15645300 申请日：2017-07-10
- 公开(公告)号：US20170304305A1 公开(公告)日：2017-10-26
- 发明人： Yanyan DONG , Shih CHENGKON
- 申请人： XUANZHU PHARMA CO., LTD.
- 优先权： CN201010266177.8 20100830
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; A61K45/06 ; C07D491/08 ; C07D487/10 ; C07D487/08 ; C07D487/04 ; C07D471/10 ; C07D471/08 ; C07D471/04 ; C07D451/06 ; C07D451/02 ; C07D413/14 ; C07D409/12 ; C07D405/12 ; C07D403/14 ; C07D403/12 ; C07D401/12 ; C07D239/94 ; C07D239/86 ; C07D491/107 ; C07D493/08
摘要：
The invention relates to quinazoline derivatives substituted by aniline which are represented by the below formula (I), pharmaceutical acceptable salts and stereoisomer thereof, wherein these groups of R1, R2, R3, R4, R5, R6, L and n have the meanings given in the specification. The invention also relates to preparation methods, pharmaceutical compositions, pharmaceutical preparation and the use for preparation of medicine of treating excessive hyperplasia and chronic obstructive pulmonary disease and uses for treating excessive hyperplasia and chronic obstructive pulmonary disease thereof.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/50 | ....哒嗪；氢化哒嗪 |
| ----------------A61K31/517 | .....与碳环系统邻位或迫位稠合的，例如喹唑啉、萘嵌间二氮杂苯 |