The present invention discloses a liquid crystal composition, comprising: at least a first compound selected from the group consisting of a compound of general Formula I-1, a compound of general Formula I-2, and a combination thereof, and at least a second compound selected from the group consisting of a compound of general Formula II-1, a compound of general Formula II-2, a compound of general Formula II3, a compound of general Formula II-4 and a combination thereof The liquid crystal composition provided in the present invention has the properties of appropriate optical and dielectric anisotropies, high clearing point, existence of a nematic phase over a wide range of temperature, low viscosity and good high-temperature stability. The liquid crystal composition is applicable to a liquid crystal display (LCD) device, to enable the LCD device to have such properties as short response time, excellent display effect at high temperature, and others.