基本信息:
- 专利标题： SHIP1 MODULATORS AND METHODS RELATED THERETO
- 申请号：US15370973 申请日：2016-12-06
- 公开(公告)号：US20170224682A1 公开(公告)日：2017-08-10
- 发明人： Lloyd F. MACKENZIE , Thomas B. MACRURY , Curtis HARWIG , David BOGUCKI , Jeffery R. RAYMOND , Jeremy D. PETTIGREW , Vladimir KHLEBNIKOV , Rudong SHAN
- 申请人： AQUINOX PHARMACEUTICALS (CANADA) INC.
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965 ; A61K31/122 ; A61K31/135 ; A61K31/085 ; A61K31/05 ; A61K31/192 ; A61K31/09 ; A61K31/167 ; A61K31/165 ; A61K31/277 ; A61K31/095 ; A61K31/166 ; A61K31/4402 ; A61K31/4164 ; A61K31/4196 ; A61K31/495 ; A61K31/155 ; A61K31/4406 ; A61K31/4465 ; A61K31/10 ; A61K31/443 ; A61K31/444 ; A61K31/4439 ; A61K31/496 ; A61K31/12
摘要：
Compounds of formula (I): where n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
公开/授权文献:
- US09937167B2 SHIP1 modulators and methods related thereto 公开/授权日：2018-04-10
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/4965 | ....非稠合的吡嗪 |