基本信息:
- 专利标题： TARGETED PHARMACOLOGICAL CHAPERONES
- 申请号：US15477569 申请日：2017-04-03
- 公开(公告)号：US20170216451A1 公开(公告)日：2017-08-03
- 发明人： John Joseph Naleway , Fiona Karen Harlan , Jason Scott Lusk
- 申请人： Marker Gene Technologies, Inc.
- 专利权人： Marker Gene Technologies, Inc.
- 当前专利权人： Marker Gene Technologies, Inc.
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61K31/445 ; C07K19/00
摘要：
The present invention relates to the preparation End use of therapeutic compounds for the treatment of diseases at specific subcellular target areas such as specific cellular organelles. In particular, the therapeutic compounds of the invention are specific for modifying enzyme activity within targeted organelles or structures of cells and tissues. Subcellular organelles and structures that may be specifically targeted by compounds of the present invention include lysosomes, autophagasomes, the endoplasmic reticulum, the Golgi complex, peroxisomes, the nucleus, membranes and the mitochondria.
公开/授权文献:
- US09925271B2 Targeted pharmacological chaperones 公开/授权日：2018-03-27
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K47/00 | 以所用的非有效成分为特征的医用配制品，如载体、惰性添加剂 |
| --------A61K47/48 | .非有效成分被化学键键合到有效成分上，例如聚合物药物轭合物 |