发明申请
US20170002008A1 BICYCLOAMINE-SUBSTITUTED-N-BENZENESULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS
有权
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基本信息:
- 专利标题: BICYCLOAMINE-SUBSTITUTED-N-BENZENESULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS
- 专利标题(中):具有选择性活性的双环胺取代的N-苯并呋喃胺化合物在电压筛选的钠通道中
- 申请号:US15038805 申请日:2014-11-24
- 公开(公告)号:US20170002008A1 公开(公告)日:2017-01-05
- 发明人: Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Dansu Li , Xiu Wang , Xuanjia Peng
- 申请人: Dansu LI , Mark E. LAYTON , Anthony J. ROECKER , Melissa EGBERTSON , Kristen L. G. JONES , Xiu WANG , Xuanjia PENG , MERCK SHARP & DOHME CORP.
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 优先权: CNPCT/CN2013/001476 20131129
- 国际申请: PCT/US14/67001 WO 20141124
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; C07D487/10 ; C07D471/04 ; C07D285/135 ; C07D213/76 ; C07D239/42 ; C07D237/20 ; C07D491/20 ; C07D277/52
摘要:
Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.
摘要(中):
公开了式A-a或其盐的化合物:其中“B1”和“R1”至“R5”如本文所定义,这些化合物具有阻断外周和交感神经元中的Nav 1.7离子通道的性质。 还描述了包含式A-a化合物或其盐的药物制剂,以及使用其制备神经性疼痛病症的方法。
公开/授权文献:
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D487/00 | 在稠环系中含有氮原子作为仅有的杂环原子的杂环化合物,不包含在C07D451/00至C07D477/00组中 |
--------C07D487/02 | .在稠合系中含有两个杂环 |
----------C07D487/04 | ..邻位稠合系 |