基本信息:
- 专利标题： BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
- 专利标题（中）：苯并咪唑衍生物作为BROMODOMAIN抑制剂
- 申请号：US15239422 申请日：2016-08-17
- 公开(公告)号：US20160376261A1 公开(公告)日：2016-12-29
- 发明人： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Rick Lee , Ruben Martinez , Samuel E. Metobo , Michael Mish , Manuel Munoz , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
- 申请人： Gilead Sciences, Inc.
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; C07D453/02 ; C07D417/14 ; C07D413/14 ; C07D471/04
摘要：
This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.
摘要（中）：
其中R1a，R1b，R2a，R2b，R3，R4a，R4b和R5如本文所述。
公开/授权文献:
- US10017501B2 Benzimidazole derivatives as bromodomain inhibitors 公开/授权日：2018-07-10
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D413/00 | 杂环化合物，含两个或更多个杂环，至少有1个环有氮原子和氧原子作为仅有的杂环原子 |
| --------C07D413/02 | .含两个杂环 |
| ----------C07D413/04 | ..被环原子—环原子的键直接连接的 |