Bottom-loading bottled water dispensers are disclosed that include hot water sanitizing capabilities (and, optionally, UV light sanitizing features). The dispensers include a water bottle that is operably connected to a pump that is configured to extract water from the bottle and force the water through one or more tubes and into a cold tank. The cold tank includes an evaporator that is configured to chill the water in the cold tank. The dispensers further include a hot tank that is fluidly coupled to the cold tank through one or more tubes, with the hot tank being attached to a heating element that is configured to heat the water in the hot tank. In addition, the dispensers include an electronic control board that is configured to heat a volume of water contained in the cold tank above a defined threshold temperature and for a defined period of time that is effective to sanitize the internal surfaces of the cold tank.