![COMPOSITIONS AND METHODS FOR ACTIVATING SILENT GENE CLUSTERS](/abs-image/US/2016/12/01/US20160348097A1/abs.jpg.150x150.jpg)
基本信息:
- 专利标题: COMPOSITIONS AND METHODS FOR ACTIVATING SILENT GENE CLUSTERS
- 专利标题(中):用于激活静电基因簇的组合物和方法
- 申请号:US15167224 申请日:2016-05-27
- 公开(公告)号:US20160348097A1 公开(公告)日:2016-12-01
- 发明人: Oliver LIU , Jeffrey Hoon KIM
- 申请人: Radiant Genomics, Inc.
- 主分类号: C12N15/10
- IPC分类号: C12N15/10 ; C12N7/00 ; C12N15/76
摘要:
The disclosure provides compositions and methods for producing natural products in microorganisms that are otherwise unexpressed, poorly expressed or poorly transcribed. In particular aspects, the disclosure provides compositions and methods for activating a silent gene or gene cluster with a bacteriophage and/or Streptomyces Antibiotic Regulatory Protein (SARP) transcription factor.
摘要(中):
本公开提供了用于在微生物中生产天然产物的组合物和方法,否则其未表达,表达差或转录不良。 在具体方面,本公开提供了用噬菌体和/或抗链霉菌抗生素调节蛋白(SARP)转录因子激活沉默基因或基因簇的组合物和方法。