Heat transfer compositions, methods, efficiencies, and systems are disclosed. The compositions have four or more heat transfer components/constituents that have been selected such that the compositions provide an operating performance and energy efficiency that are comparable to, or better than, the performance of R22 and currently available R22 replacements. The four or more constituents have sequenced boiling temperatures that work together to extend the phase change, thereby elongating the heat absorption phase and increasing efficiency. In some embodiments the heat transfer constituents include 15-25% by weight R32, 1-5% by weight R125, 50-70% by weight R134a, and 10-20% by weight R227ea. The compositions may also include 0.5-3.5% by weight R236.