发明申请
US20160220651A1 IMMUNOGENIC TUMOR ASSOCIATED STROMAL CELL ANTIGEN PEPTIDES AND METHODS OF THEIR USE
有权

基本信息:
- 专利标题: IMMUNOGENIC TUMOR ASSOCIATED STROMAL CELL ANTIGEN PEPTIDES AND METHODS OF THEIR USE
- 专利标题(中):免疫原性肿瘤相关抗原细胞抗原肽及其使用方法
- 申请号:US15133038 申请日:2016-04-19
- 公开(公告)号:US20160220651A1 公开(公告)日:2016-08-04
- 发明人: Walter J. Storkus , Anamika Bose , Jennifer Lynn Taylor , Xi Zhao , Devin B. Lowe
- 申请人: University of Pittsburgh - Of the Commonwealth S ystem of Higher Education
- 申请人地址: US Pittsburgh
- 专利权人: University of Pittsburgh - Of the Commonwealth S ystem of Higher Education
- 当前专利权人: University of Pittsburgh - Of the Commonwealth S ystem of Higher Education
- 当前专利权人地址: US Pittsburgh
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; C12N5/0783 ; A61K31/506
摘要:
Immunogenic peptides from tumor associated stromal cell antigens, including combinations of such peptides, are disclosed herein. In some examples the peptides are useful for methods of eliciting an immune response. In additional examples the peptides are useful for methods of treating cancer. Methods for decreasing vascularization of a tumor using a Protein Delta Homolog 1 (DLK1) protein or a nucleic acid encoding the protein are also disclosed.
摘要(中):
来自肿瘤相关基质细胞抗原的免疫原性肽,包括这些肽的组合,在此公开。 在一些实例中,肽可用于引发免疫应答的方法。 在另外的实施例中,肽可用于治疗癌症的方法。 还公开了使用Protein Delta Homolog 1(DLK1)蛋白或编码该蛋白质的核酸降低肿瘤血管化的方法。
公开/授权文献:
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K39/00 | 含有抗原或抗体的医药配制品 |