发明申请
US20160129105A1 PHARMACEUTICAL COMPOSITION CONTAINING A STABILISED mRNA OPTIMISED FOR TRANSLATION IN ITS CODING REGIONS
审中-公开
基本信息:
- 专利标题： PHARMACEUTICAL COMPOSITION CONTAINING A STABILISED mRNA OPTIMISED FOR TRANSLATION IN ITS CODING REGIONS
- 申请号：US14994913 申请日：2016-01-13
- 公开(公告)号：US20160129105A1 公开(公告)日：2016-05-12
- 发明人： Florian VON DER MÜLBE , Ingmar HOERR , Steve PASCOLO
- 申请人： CureVac AG
- 申请人地址： DE Tubingen
- 专利权人： CureVac AG
- 当前专利权人： CureVac AG
- 当前专利权人地址： DE Tubingen
- 优先权： DEDE10127283.9 20010605
- 主分类号： A61K39/145
- IPC分类号： A61K39/145 ; A61K38/19
摘要：
The present invention relates to a pharmaceutical composition comprising a modified mRNA that is stabilised by sequence modifications and optimised for translation. The pharmaceutical composition according to the invention is particularly well suited for use as an inoculating agent, as well as a therapeutic agent for tissue regeneration. In addition, a process is described for determining sequence modifications that promote stabilisation and translational efficiency of modified mRNA of the invention.
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/12 | .病毒性抗原 |
| ----------A61K39/145 | ..正黏液病毒科，例如流感病毒属 |