
基本信息:
- 专利标题: MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF
- 专利标题(中):5-HT受体的调节剂及其使用方法
- 申请号:US14887171 申请日:2015-10-19
- 公开(公告)号:US20160096851A1 公开(公告)日:2016-04-07
- 发明人: Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
- 申请人: AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
- 主分类号: C07D513/04
- IPC分类号: C07D513/04 ; C07D491/044 ; C07D495/16 ; C07D487/04
摘要:
The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要(中):
本申请涉及式(I)的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平,二氢八氢化吡咯并噻吩,十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物,其中R1,R2,R3,R4,R5,A,Y1 ,Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物,制备此类化合物的方法,以及使用这些化合物和组合物治疗疾病状况的方法,以及鉴定这些化合物的方法。
公开/授权文献:
- US09879033B2 Modulators of 5-HT receptors and methods of use thereof 公开/授权日:2018-01-30
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D513/00 | 杂环化合物,在稠环系中至少有1个杂环具有氮原子和硫原子作为仅有的杂环原子,不包含在C07D463/00、C07D477/00或C07D499/00至C07D507/00组中 |
--------C07D513/02 | .稠环系中含有两个杂环 |
----------C07D513/04 | ..邻位稠合系 |