发明申请
US20150023873A1 EVALUATION OF PRESENCE OF AND VULNERABILITY TO ATRIAL FIBRILLATION AND OTHER INDICATIONS USING MATRIX METALLOPROTEINASE-BASED IMAGING
审中-公开

基本信息:
- 专利标题: EVALUATION OF PRESENCE OF AND VULNERABILITY TO ATRIAL FIBRILLATION AND OTHER INDICATIONS USING MATRIX METALLOPROTEINASE-BASED IMAGING
- 专利标题(中):使用基于基质金属蛋白酶的成像对ATRIAL FIBRILLATION和其他适应症的存在和易感性的评估
- 申请号:US14357555 申请日:2012-10-31
- 公开(公告)号:US20150023873A1 公开(公告)日:2015-01-22
- 发明人: Albert J. Sinusas , Joseph G. Akar , Richard R. Cesati , Heike S. Radeke , Stephen B. Haber
- 申请人: Lantheus Medical Imaging, Inc. , Yale University
- 申请人地址: US MA North Billerica US CT New Haven
- 专利权人: Lantheus Medical Imaging, Inc.,Yale University
- 当前专利权人: Lantheus Medical Imaging, Inc.,Yale University
- 当前专利权人地址: US MA North Billerica US CT New Haven
- 国际申请: PCT/US2012/062863 WO 20121031
- 主分类号: A61K51/04
- IPC分类号: A61K51/04 ; A61K51/08
摘要:
The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining MMP levels.
摘要(中):
在一些实施方案中,本发明提供了与评估增加的心房颤动(AF)的风险相关的方法和/或使用包含与成像部分连接的MMP抑制剂的成像剂对特定AF治疗作出响应的可能性。 本发明进一步提供了通过测定MMP水平来评估是否存在发展其他心血管疾病的风险的方法以及评估治疗或其他介入治疗或其他干预措施的有效性的方法。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K51/00 | 用于治疗或体内测试用的含有放射性物质的配制品 |
--------A61K51/02 | .以载体为特征 |
----------A61K51/04 | ..有机化合物 |