基本信息:
- 专利标题： INTEGRATED ILLUMINATION OF OPTICAL ANALYTICAL DEVICES
- 专利标题（中）：光学分析装置的集成照明
- 申请号：US14187198 申请日：2014-02-21
- 公开(公告)号：US20140287964A1 公开(公告)日：2014-09-25
- 发明人： Paul LUNDQUIST , Stephen TURNER
- 申请人： Pacific Biosciences of California, Inc.
- 申请人地址： US CA Menlo Park
- 专利权人： PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
- 当前专利权人： PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
- 当前专利权人地址： US CA Menlo Park
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include integrated illumination elements and optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.
摘要（中）：
提供光学分析装置及其使用方法。 该装置可用于高密度高分复用的光学反应，包括生化反应，如核酸测序反应。 这些器件包括用于照射光学反应的集成照明元件和光波导。 这些器件进一步提供了从波导到光学反应的光学激发能量的有效耦合。 因此，可以以高灵敏度和使用诸如光谱，振幅和时间分辨率等特征或其组合的鉴别来测量从反应发射的光信号。 本发明的装置非常适合于小型化和高产量。
公开/授权文献:
- US09624540B2 Integrated illumination of optical analytical devices 公开/授权日：2017-04-18