发明申请
US20140194416A1 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS
有权
基本信息:
- 专利标题： N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS
- 专利标题（中）：N-羟基磺酰胺衍生物作为新的生理上有用的硝基苯衍生物
- 申请号：US14204636 申请日：2014-03-11
- 公开(公告)号：US20140194416A1 公开(公告)日：2014-07-10
- 发明人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
- 申请人： Cardioxyl Pharmaceuticals, Inc. , The Johns Hopkins University
- 申请人地址： US NC Chapel Hill US MD Baltimore
- 专利权人： Cardioxyl Pharmaceuticals, Inc.,The Johns Hopkins University
- 当前专利权人： Cardioxyl Pharmaceuticals, Inc.,The Johns Hopkins University
- 当前专利权人地址： US NC Chapel Hill US MD Baltimore
- 主分类号： C07C317/48
- IPC分类号： C07C317/48 ; C07D295/155 ; C07D295/26 ; C07D333/36 ; C07D295/16
摘要：
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
摘要（中）：
本发明涉及在生理条件下提供硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注 伤害。 新型N-羟基磺酰胺衍生物在生理条件下以控制速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C317/00 | 砜；亚砜 |
| --------C07C317/26 | .有砜基或亚砜基和不属于硝基或亚硝基的氮原子连接在同一碳架上 |
| ----------C07C317/48 | ..碳架进一步被单键氮原子取代，该氮原子不属于硝基或亚硝基 |