
基本信息:
- 专利标题: PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES
- 专利标题(中):制备吡唑羧酸酰胺的方法
- 申请号:US13981913 申请日:2012-01-25
- 公开(公告)号:US20130310592A1 公开(公告)日:2013-11-21
- 发明人: Miroslav Terinek , Dominik Faber , Stefan Koenig
- 申请人: Miroslav Terinek , Dominik Faber , Stefan Koenig
- 申请人地址: CH Basel
- 专利权人: SYNGENTA PARTICIPATIONS AG
- 当前专利权人: SYNGENTA PARTICIPATIONS AG
- 当前专利权人地址: CH Basel
- 优先权: EP11151965.8 20110125
- 国际申请: PCT/EP2012/051075 WO 20120125
- 主分类号: C07D231/14
- IPC分类号: C07D231/14 ; C07C251/56
摘要:
The invention relates to a process for the preparation of 3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxylic acid (9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide by acylating the oxime oxygen of the compound of formula (VIII), in the presence of a solvent and an acylating agent of formula (XI) R 1C(X)—CI (XI); wherein X is oxygen or sulfur; R1 is chloro if X is oxygen or sulfur; or R1 is C1-C6alkoxy, CH3—C(═CH2)-0-, phenoxy or trichloromethoxy if X is oxygen; and a) if R1 is chloro and the compound of formula (XI) was added to the compound of formula (VIII); reacting the so obtained product of formula (XIIa) wherein X is oxygen or sulfur; with the compound of formula (IX) b) if R1 is chloro and the compound of formula (VIII) was added to the compound of formula (XI); or R1 is C1-C6alkoxy, CH3—C(═CH2)-0-, phenoxy or trichloromethoxy if X is oxygen; reacting the so obtained product of formula (XII) wherein X is oxygen or sulfur; R1 is chloro if X is oxygen or sulfur; or R1 is C1-C6alkoxy, CH3—C(═CH2)-0-, phenoxy or trichloromethoxy if X is oxygen; with the compound of formula (IX).
摘要(中):
本发明涉及制备3-二氟甲基-1-甲基-1H-吡唑-4-羧酸(9-二氯亚甲基-1,2,3,4-四氢-1,4-亚甲基 - 萘-1-基) (XI)R 1C(X)-CI(XI)的溶剂和酰化剂的存在下酰化式(Ⅷ)化合物的肟氧; 其中X是氧或硫; 如果X是氧或硫,则R1是氯; 或者如果X是氧,R 1是C 1 -C 6烷氧基,CH 3 C(= CH 2)-O-,苯氧基或三氯甲氧基; 和a)如果R1是氯,并且将式(XI)化合物加入到式(VIII)化合物中; 使所得的式(XIIa)化合物与X为氧或硫反应; 与式(Ⅸ)化合物b)如果R 1是氯,并将式(Ⅷ)化合物加到式(Ⅺ)化合物中; 或者如果X是氧,R 1是C 1 -C 6烷氧基,CH 3 C(= CH 2)-O-,苯氧基或三氯甲氧基; 使所得的式(XII)化合物(其中X是氧或硫)反应; 如果X是氧或硫,则R1是氯; 或者如果X是氧,R 1是C 1 -C 6烷氧基,CH 3 C(= CH 2)-O-,苯氧基或三氯甲氧基; 与式(IX)的化合物反应。
公开/授权文献:
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D231/00 | 杂环化合物,含1,2-二唑或氢化1,2-二唑环 |
--------C07D231/02 | .不与其他环稠合 |
----------C07D231/06 | ..环原子间或环原子与非环原子间有1个双键 |
------------C07D231/14 | ...有杂原子或有以3个键连杂原子、其中最多以1个键连卤素的碳原子,例如,酯基或腈基,直接与环碳原子相连 |