发明申请
US20130190350A1 Mediators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto
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基本信息:
- 专利标题： Mediators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto
- 申请号：US13712525 申请日：2012-12-12
- 公开(公告)号：US20130190350A1 公开(公告)日：2013-07-25
- 发明人： Lee L. RUBIN , Oivin GUICHERIT , Stephen PRICE , Edward Andrew BOYD
- 申请人： Curis, Inc.
- 申请人地址： US MA Lexington
- 专利权人： CURIS, INC.
- 当前专利权人： CURIS, INC.
- 当前专利权人地址： US MA Lexington
- 主分类号： C07D263/57
- IPC分类号： C07D263/57 ; C07D235/18 ; C07D401/12 ; C07D405/12 ; C07D471/04 ; C07D413/12
摘要：
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D263/00 | 杂环化合物，含有1,3-唑环或氢化1,3-唑环 |
| --------C07D263/02 | .不和其他环稠合 |
| ----------C07D263/54 | ..苯并唑；氢化苯并唑 |
| ------------C07D263/56 | ...仅有氢原子、烃基或取代烃基，直接连在位置2上 |
| --------------C07D263/57 | ....芳基或取代的芳基 |