发明申请
US20130102780A1 TRANSITION METAL-CATALYZED PROCESSES FOR THE PREPARATION OF N-ALLYL COMPOUNDS AND USE THEREOF
有权
基本信息:
- 专利标题： TRANSITION METAL-CATALYZED PROCESSES FOR THE PREPARATION OF N-ALLYL COMPOUNDS AND USE THEREOF
- 申请号：US13711520 申请日：2012-12-11
- 公开(公告)号：US20130102780A1 公开(公告)日：2013-04-25
- 发明人： Joshua Robert GIGUERE , Keith Edward MCCARTHY , Helge Alfred REISCH , Sergio SANDOVAL , Jake Larry STYMIEST
- 申请人： Rhodes Technologies
- 申请人地址： US RI Coventry
- 专利权人： Rhodes Technologies
- 当前专利权人： Rhodes Technologies
- 当前专利权人地址： US RI Coventry
- 主分类号： C07D489/08
- IPC分类号： C07D489/08 ; C07C269/04 ; C07C209/44 ; C07D265/30
摘要：
The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D489/00 | 杂环化合物，含有4aH-8,9c-亚氨基桥亚乙基菲并［4,5-b,c,d］呋喃环系，例如下式的 |
| --------C07D489/02 | .有氧原子连在位置3和6上，例如吗啡、玛啡酮 |
| ----------C07D489/08 | ..氧原子 |