基本信息:
- 专利标题： IMMUNOGENIC POTE PEPTIDES AND METHODS OF USE
- 申请号：US13610421 申请日：2012-09-11
- 公开(公告)号：US20130039936A1 公开(公告)日：2013-02-14
- 发明人： Jay A. Berzofsky , Yi-Hsiang Huang , Masaki Terabe , Ira H. Pastan
- 申请人： Jay A. Berzofsky , Yi-Hsiang Huang , Masaki Terabe , Ira H. Pastan
- 专利权人： The United States of America, as represented by the Secretary, Dept. of Health & Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Dept. of Health & Human Services
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61P35/00 ; C12N15/12 ; C12N15/63 ; C07K7/06 ; C07K19/00
摘要：
POTE has recently been identified as a tumor antigen expressed in a variety of human cancers, including colon, ovarian, breast, prostate, lung and pancreatic cancer. Described herein are immunogenic POTE polypeptides, including modified POTE polypeptides, that bind MHC class I molecules. The immunogenic POTE polypeptides are capable of inducing an immune response against POTE-expressing tumor cells. Thus, provided herein is a method of eliciting an immune response in a subject, such as a subject having a type of cancer that expresses POTE.
公开/授权文献:
- US08871902B2 Immunogenic POTE peptides and methods of use 公开/授权日：2014-10-28
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |