发明申请
US20130011417A1 COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES
有权
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基本信息:
- 专利标题: COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES
- 专利标题(中):化合物衍生物或其药学上可接受的盐,制备所述衍生物的方法和包含所述衍生物的药物组合物
- 申请号:US13579704 申请日:2011-02-18
- 公开(公告)号:US20130011417A1 公开(公告)日:2013-01-10
- 发明人: Duck Jong Han , Sung-eun Yoo , Jeehee Suh
- 申请人: Duck Jong Han , Sung-eun Yoo , Jeehee Suh
- 优先权: KR10-2010-0014811 20100218
- 国际申请: PCT/KR2011/001087 WO 20110218
- 主分类号: A61K31/27
- IPC分类号: A61K31/27 ; C07C233/32 ; A61K31/165 ; A61P37/06 ; A61K31/17 ; A61K39/00 ; A61K39/395 ; C07C271/30 ; C07C275/26
摘要:
The present invention relates to colchicine derivatives expressed in chemical formula 1, or to pharmaceutically acceptable salts thereof, to a method for preparing said derivatives, and to a pharmaceutical composition comprising said derivatives. The colchicine derivatives according to the present invention exhibit superior immunomodulatory effects as compared with conventional immunomodulators or colchicines, and therefore can be valuably used as an immunomodulator for modulating an acute or chronic immune response in organ transplantation.
摘要(中):
本发明涉及化学式1表示的秋水仙碱衍生物或其药学上可接受的盐,涉及制备所述衍生物的方法,以及包含所述衍生物的药物组合物。 根据本发明的秋水仙碱衍生物与常规的免疫调节剂或秋水仙素相比表现出优异的免疫调节作用,因此可以有价值地用作调节器官移植中急性或慢性免疫应答的免疫调节剂。
公开/授权文献:
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/045 | .羟基化合物,例如醇类;其盐类,例如醇化物 |
----------A61K31/27 | ..氨基甲酸或硫代氨基甲酸的酯,如甲丙氨酯、卡巴胆碱、新斯的明 |