发明申请
US20120115823A1 BISMUTH-CONTAINING COMPOUNDS, COORDINATION POLYMERS, METHODS FOR MODULATING PHARMACOKINETIC PROPERTIES OF BIOLOGICALLY ACTIVE AGENTS, AND METHODS FOR TREATING PATIENTS
审中-公开
基本信息:
- 专利标题： BISMUTH-CONTAINING COMPOUNDS, COORDINATION POLYMERS, METHODS FOR MODULATING PHARMACOKINETIC PROPERTIES OF BIOLOGICALLY ACTIVE AGENTS, AND METHODS FOR TREATING PATIENTS
- 专利标题（中）：含双硫酸化合物，协调聚合物，调节生物活性剂的药代动力学性质的方法以及治疗患者的方法
- 申请号：US12941599 申请日：2010-11-08
- 公开(公告)号：US20120115823A1 公开(公告)日：2012-05-10
- 发明人： John D. Price , Thomas Piccariello , Robert A. Oberlender , Michaela E. Mulhare , Scott B. Palmer
- 申请人： John D. Price , Thomas Piccariello , Robert A. Oberlender , Michaela E. Mulhare , Scott B. Palmer
- 主分类号： A61K31/29
- IPC分类号： A61K31/29 ; C07K2/00 ; C07H23/00 ; C08B37/04 ; C08B37/06 ; C08B37/08 ; C08B37/00 ; C08B11/08 ; A61K31/606 ; A61P35/00 ; A61P29/00 ; A61P1/00 ; A61P5/14 ; A61P25/16 ; C07F9/94
摘要：
Bismuth-containing compounds include bismuth and a biologically active agent coordinated to the bismuth. The biologically active agent includes at least one heteroatom configured for coordination with the bismuth. Coordination polymers include a polymer matrix that contains a bismuth-containing compound. Methods for modulating a pharmacokinetic property of a biologically active agent include coordinating the biologically active agent to bismuth to form a bismuth-containing compound, and administering the bismuth-containing compound orally to a patient. Methods for treating Parkinson's disease, methods for treating hypothyroidism, methods for treating ulcerative colitis, and methods for treating cancer each include administering a bismuth-containing compound to a patient.
摘要（中）：
含铋的化合物包括铋和与铋配位的生物活性剂。 生物活性剂包括至少一个配置成与铋配位的杂原子。 配位聚合物包括含有含铋化合物的聚合物基质。 用于调节生物活性剂的药代动力学性质的方法包括将生物活性剂与铋配位以形成含铋化合物，并向患者口服给含铋的化合物。 用于治疗帕金森病的方法，治疗甲状腺功能减退的方法，治疗溃疡性结肠炎的方法以及治疗癌症的方法均包括向患者施用含铋的化合物。
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/29 | ..锑或铋的化合物 |