
基本信息:
- 专利标题: METHODS FOR MAKING AND USING SPR MICROARRAYS
- 专利标题(中):制备和使用SPR微量元素的方法
- 申请号:US13337506 申请日:2011-12-27
- 公开(公告)号:US20120115748A1 公开(公告)日:2012-05-10
- 发明人: Nicholas Adam WOLF , Danliang JIN , Anna BARKLUND , Raluca DINU
- 申请人: Nicholas Adam WOLF , Danliang JIN , Anna BARKLUND , Raluca DINU
- 申请人地址: US WA Woodinville
- 专利权人: PLEXERA LLC
- 当前专利权人: PLEXERA LLC
- 当前专利权人地址: US WA Woodinville
- 主分类号: C40B30/04
- IPC分类号: C40B30/04 ; C40B40/10 ; C40B40/06 ; G01N21/55 ; C40B40/04
摘要:
An article, process, and method for surface plasmon resonance plates are described. A substrate is covered with a thin metal film onto which a second thin metal film is deposited. The surface of the second thin metal film is converted to the metal oxide which is used to covalently bond organosilanes to the surface. Reactive organosilanes containing terminal bonding groups are arranged in a plurality of spots that are surrounded by inert organosilanes. Biomolecule attachment to the binding group is detected or measured from surface plasmon signals from the first thin metal film.
摘要(中):
描述了表面等离子体共振板的制品,工艺和方法。 衬底被薄金属膜覆盖,其上沉积有第二薄金属膜。 将第二薄金属膜的表面转化为用于将有机硅烷共价键合到表面的金属氧化物。 含有末端键合基团的反应性有机硅烷排列成被惰性有机硅烷包围的多个点。 从第一薄金属膜的表面等离子体信号检测或测量与结合基团的生物分子附着。
IPC结构图谱:
C | 化学;冶金 |
--C40 | 组合技术 |
----C40B | 组合化学;化合物库,如化学库、虚拟库 |
------C40B30/00 | 筛选化合物库的方法 |
--------C40B30/04 | .通过测定对靶分子特殊结合能力,如抗体-抗原结合、受体-配体结合能力 |