发明申请
US20110262570A1 Transcriptional Profiling and Biomarker-Based Methods for Identifying and Evaluating Agents for Antioxidant Efficacy in Cosmetic Skin Care Formulations
审中-公开
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基本信息:
- 专利标题: Transcriptional Profiling and Biomarker-Based Methods for Identifying and Evaluating Agents for Antioxidant Efficacy in Cosmetic Skin Care Formulations
- 专利标题(中):用于鉴定和评价化妆品护肤制剂中抗氧化功效的代谢分析和基于生物标志物的方法
- 申请号:US13022191 申请日:2011-02-07
- 公开(公告)号:US20110262570A1 公开(公告)日:2011-10-27
- 发明人: Deborah Ruth Finlay , Robert Lloyd Binder , Michael Keith Robinson , Rosemarie Osborne , Lisa Ann Mullins
- 申请人: Deborah Ruth Finlay , Robert Lloyd Binder , Michael Keith Robinson , Rosemarie Osborne , Lisa Ann Mullins
- 主分类号: A61K8/97
- IPC分类号: A61K8/97 ; C07D339/04 ; A61K8/36 ; A61K8/49 ; C12Q1/68 ; A61Q19/00 ; A61Q19/08 ; C40B40/08 ; C40B40/06 ; C40B30/04 ; C07C57/00 ; A61K8/67
摘要:
Gene panels, microarrays and biomarker panels relating to genes and gene products associated with age-related oxidative damage to skin, and transcriptional profiling-based methods for identification and evaluation of cosmetic agents for prevention, reversal, or reduction of oxidative damage to skin. Cosmetic agents and compositions comprising the cosmetic agents, capable of inducing nrf2-mediated activation of the antioxidant response element to increase expression of Phase 2 enzymes, methods for restoring optimal redox status to skin employing the agents, and methods for identifying and evaluating cosmetic agents acting via the nrf2-mediated mechanism.
摘要(中):
与与年龄相关的对皮肤的氧化损伤相关的基因和基因产物的基因组,微阵列和生物标记面板以及用于鉴定和评价化妆品以预防,逆转或减少对皮肤的氧化损伤的基于转录谱的方法。 包含化妆品的化妆品和组合物,其能够诱导nrf2介导的抗氧化反应元件的活化以增加阶段2酶的表达,使用该试剂恢复对皮肤的最佳氧化还原状态的方法,以及用于鉴定和评估作用的化妆品的方法 通过nrf2介导的机制。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K8/00 | 化妆品或类似的梳妆用配制品 |
--------A61K8/02 | .以特殊的物理形状为特征 |
----------A61K8/96 | ..含结构未确定的原料,或其衍生物 |
------------A61K8/97 | ...源自植物的,例如,植物提取物 |