发明申请
US20110237858A1 Device and Methods for Sequential, Regional Delivery of Multiple Cytotoxic Agents and Directed Assembly of Wound Repair Tissues
有权
![Device and Methods for Sequential, Regional Delivery of Multiple Cytotoxic Agents and Directed Assembly of Wound Repair Tissues](/abs-image/US/2011/09/29/US20110237858A1/abs.jpg.150x150.jpg)
基本信息:
- 专利标题: Device and Methods for Sequential, Regional Delivery of Multiple Cytotoxic Agents and Directed Assembly of Wound Repair Tissues
- 专利标题(中):用于连续,区域递送多种细胞毒剂的装置和方法以及定向组装伤口修复组织
- 申请号:US13117209 申请日:2011-05-27
- 公开(公告)号:US20110237858A1 公开(公告)日:2011-09-29
- 发明人: John H. Brekke , John H. Gubbe
- 申请人: John H. Brekke , John H. Gubbe
- 申请人地址: US PA Exton
- 专利权人: Kensey Nash Corporation
- 当前专利权人: Kensey Nash Corporation
- 当前专利权人地址: US PA Exton
- 主分类号: A61N5/00
- IPC分类号: A61N5/00 ; A61M5/00
摘要:
An implantable delivery system includes a macrostructure formed of bioresorbable material selected from a group of alphahydroxy acids and defined to include an internal architecture of intercommunicating void spaces. A first cytotoxic agent in the preferred form of cisplatin is joined to the macrostructure during formation. A microstructure in the preferred form of a blend of high molecular weight hyaluronic acid conjugated with a second cytotoxic agent in the preferred form of paclitaxel and of pure high molecular weight hyaluronic acid is invested in the void spaces. Thus, when implanted, the paclitaxel and cisplatin are released sequentially, each initially at high level concentrations followed by lower release. Radiotherapy can be begun after the release of the paclitaxel has been completed but while the cisplatin is being released.
摘要(中):
可植入递送系统包括由生物可再吸收材料形成的宏观结构,所述生物可吸收材料选自α-羟基酸,并且被定义为包括相互通信的空隙空间的内部结构。 优选形式的顺铂的第一种细胞毒性剂在形成过程中与宏观结构相结合。 在优选形式的紫杉醇和纯高分子量透明质酸中与第二细胞毒剂偶联的高分子量透明质酸的混合物的优选形式的微结构被投入到空隙空间中。 因此,当植入时,依次释放紫杉醇和顺铂,各自最初以高浓度浓度释放。 在紫杉醇释放已经完成但顺铂释放之后,放射治疗可以开始。
公开/授权文献:
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61N | 电疗;磁疗;放射疗;超声波疗 |
------A61N5/00 | 放射疗 |