发明申请
US20110183856A1 Diagnosis and Prognosis of Infectious Disease Clinical Phenotypes and other Physiologic States Using Host Gene Expression Biomarkers In Blood
审中-公开
基本信息:
- 专利标题： Diagnosis and Prognosis of Infectious Disease Clinical Phenotypes and other Physiologic States Using Host Gene Expression Biomarkers In Blood
- 专利标题（中）：使用宿主基因表达生物标志物在血液中的传染病临床表型和其他生理状态的诊断和预后
- 申请号：US12713554 申请日：2010-02-26
- 公开(公告)号：US20110183856A1 公开(公告)日：2011-07-28
- 发明人： Brian K. Agan , Eric H. Hanson , Michael J. Jenkins , Baochuan Lin , Chris C. Olsen , Robb K. Rowley , David A. Stenger , Dzung C. Thach , Clark J. Tibbetts , Elizabeth A. Walter , Jinny Lin Liu
- 申请人： Brian K. Agan , Eric H. Hanson , Michael J. Jenkins , Baochuan Lin , Chris C. Olsen , Robb K. Rowley , David A. Stenger , Dzung C. Thach , Clark J. Tibbetts , Elizabeth A. Walter , Jinny Lin Liu
- 申请人地址： US DC Washington
- 专利权人： The Government of the United States of America, as represented by the Secretary of the Navy,The Government of the United States of America, as represented by the Secretary of the Air Force
- 当前专利权人： The Government of the United States of America, as represented by the Secretary of the Navy,The Government of the United States of America, as represented by the Secretary of the Air Force
- 当前专利权人地址： US DC Washington
- 主分类号： C40B30/00
- IPC分类号： C40B30/00
摘要：
The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.
摘要（中）：
本发明提供来自外周血白细胞的特异性基因表达标志物，其指示宿主对暴露，应答和恢复感染性病原体感染的反应。 本发明还提供了用于鉴定特定基因表达标志物组的方法，监测疾病进展和感染性病原体感染治疗的方法，预测感染性病原体感染发病的方法，诊断感染性病原体感染的方法以及鉴定 涉及病原体。