发明申请
US20110021511A1 SUBSTITUTED 5H-PYRIMIDO[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM
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基本信息:
- 专利标题： SUBSTITUTED 5H-PYRIMIDO[5,4-B]INDOLES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF FOR TREATING NON-SOLID MALIGNANT TUMORS OF THE BLOOD-PRODUCING SYSTEM
- 专利标题（中）：取代的5H-吡啶并[5,4-B]吲哚，其生产方法及其用于治疗血液生成系统的非固体恶性肿瘤的用途
- 申请号：US12520480 申请日：2007-12-21
- 公开(公告)号：US20110021511A1 公开(公告)日：2011-01-27
- 发明人： Claudia Reichelt , Alexander Schulze , Mohammed Daghish , Friedrich-Alexander Ludwig , Jochen Heinicke , Konrad Herrmann , Maj Schuster , Sven Letschert , Kenneth Mugridge , Joseph DeAngelo
- 申请人： Claudia Reichelt , Alexander Schulze , Mohammed Daghish , Friedrich-Alexander Ludwig , Jochen Heinicke , Konrad Herrmann , Maj Schuster , Sven Letschert , Kenneth Mugridge , Joseph DeAngelo
- 申请人地址： DE Leipzig
- 专利权人： THE MEDICINES COMPANY (LEIPZIG) GMBH
- 当前专利权人： THE MEDICINES COMPANY (LEIPZIG) GMBH
- 当前专利权人地址： DE Leipzig
- 优先权： DE102006062203 20061222
- 国际申请： PCT/EP2007/011387 WO 20071221
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61P35/02 ; A61K31/5377 ; A61P35/04 ; A61K31/496 ; A61P35/00 ; A61K31/541
摘要：
The invention relates to compounds of general formula 1 to processes for the production thereof, to pharmaceutical preparations containing said compounds and/or physiologically compatible salts and/or solvates which can be produced therefrom as well as to the pharmaceutical use of said compounds, the salts or solvates thereof as inductors of apoptosis in the case of non-solid malignant tumors of the hematopoietic system, in particular in the case of leukemias and lymphomas, more particularly in the case of leukemic B lymphocytes.
摘要（中）：
本发明涉及通式1的化合物，其制备方法，含有所述化合物的药物制剂和/或可由其制备的生理上相容的盐和/或溶剂化物以及所述化合物的药物用途，所述盐 或在造血系统的非固体恶性肿瘤的情况下，特别是在白血病和淋巴瘤的情况下，更具体地在白血病B淋巴细胞的情况下，作为细胞凋亡的感应器。
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D487/00 | 在稠环系中含有氮原子作为仅有的杂环原子的杂环化合物，不包含在C07D451/00至C07D477/00组中 |
| --------C07D487/02 | .在稠合系中含有两个杂环 |
| ----------C07D487/04 | ..邻位稠合系 |