发明申请
US20110003879A1 Antisense oligonucleotides targeted to the coding region of thymidylate synthase and uses thereof
审中-公开
基本信息:
- 专利标题： Antisense oligonucleotides targeted to the coding region of thymidylate synthase and uses thereof
- 专利标题（中）：靶向胸苷酸合酶编码区的反义寡核苷酸及其用途
- 申请号：US11908389 申请日：2006-03-13
- 公开(公告)号：US20110003879A1 公开(公告)日：2011-01-06
- 发明人： Mark D. Vincent , D. James Koropatnick
- 申请人： Mark D. Vincent , D. James Koropatnick
- 国际申请： PCT/CA06/00350 WO 20060313
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; C07H21/04 ; A61P35/00
摘要：
Antisense oligonucleotides directed to the coding region of a mammalian thymidylate synthase mRNA that are capable of inhibiting the proliferation of cancer cells without decreasing the level of thymidylate synthase mRNA in the cells are provided. The antisense oligonucleotides are also capable of inducing apoptosis in the cancer cells. The antisense oligonucleotides can be used to inhibit the proliferation of cancer cells and to induce apoptosis in cancer cells. Methods of treating cancer, and in particular breast cancer, with the antisense oligonucleotides, alone or in combination with other therapeutics, are also provided.
摘要（中）：
提供了针对能够抑制癌细胞增殖但不降低细胞中胸苷酸合酶mRNA水平的哺乳动物胸苷酸合酶mRNA编码区的反义寡核苷酸。 反义寡核苷酸也能够诱导癌细胞凋亡。 反义寡核苷酸可用于抑制癌细胞的增殖并诱导癌细胞凋亡。 还提供了用反义寡核苷酸单独或与其它治疗剂组合治疗癌症，特别是乳腺癌的方法。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/70 | .碳水化合物；糖；其衍生物 |
| ----------A61K31/7088 | ..含有3个或更多个核苷或核苷酸的化合物 |