基本信息:
- 专利标题： BIODEGRADABLE BIOACTIVE AGENT RELEASING MATRICES WITH PARTICULATES
- 专利标题（中）：可生物降解的生物活性剂释放基质
- 申请号：US12792309 申请日：2010-06-02
- 公开(公告)号：US20100303878A1 公开(公告)日：2010-12-02
- 发明人： Joram Slager , Robert Hergenrother
- 申请人： Joram Slager , Robert Hergenrother
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K38/00 ; A61F2/02 ; A61P35/00
摘要：
The present invention is directed to biodegradable polymeric matrices for the controlled release of a hydrophilic bioactive agent. Generally, the biodegradable matrices include an aliphatic polyester copolymer and microparticulates that include the hydrophilic bioactive agent. In some embodiments, the matrix includes a second biodegradable polymer comprising hydrophilic and hydrophobic portions. Exemplary matrix forms are device coatings and medical implants. Matrices of the invention demonstrated high bioactive agent loading, were able to modulate release of the bioactive agent in a therapeutic manner, and also maintained high levels of activity for therapeutically useful large molecule bioactive agents, such as proteins.
摘要（中）：
本发明涉及用于控制释放亲水生物活性剂的可生物降解的聚合物基质。 通常，生物可降解基质包括脂族聚酯共聚物和包含亲水生物活性剂的微粒。 在一些实施方案中，基质包括包含亲水和疏水部分的第二可生物降解聚合物。 示例性的矩阵形式是装置涂层和医疗植入物。 本发明的基质表现出高生物活性剂负载，能够以治疗方式调节生物活性剂的释放，并且还对治疗有用的大分子生物活性剂如蛋白质保持高水平的活性。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/395 | .抗体；免疫球蛋白；免疫血清，例如抗淋巴细胞血清 |