
基本信息:
- 专利标题: VACCINES AGAINST INFLUENZA VIRUS
- 专利标题(中):疫苗对流感病毒
- 申请号:US12541804 申请日:2009-08-14
- 公开(公告)号:US20100150954A1 公开(公告)日:2010-06-17
- 发明人: Mark A. Miller , Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Zuzana Biesova , Jerry Keith
- 申请人: Mark A. Miller , Rachel Schneerson , Joanna Kubler-Kielb , John B. Robbins , Zuzana Biesova , Jerry Keith
- 专利权人: The United States of America as represented by the Secretary, Department of Health & Human Services
- 当前专利权人: The United States of America as represented by the Secretary, Department of Health & Human Services
- 主分类号: A61K39/385
- IPC分类号: A61K39/385 ; A61P31/16 ; C07K17/06
摘要:
Disclosed are immunogenic conjugates having the general formula: M2e-Cys-S—CH2—C(O)—NH—CH2—CH2-C(O—)NH-Lys-Pr, were M2e is the influenza M2 ectodomain (M2e) peptide; Cys is a cysteine amino acid residue present in the M2e peptide; S the sulfur present in the cysteine amino acid residue; CH2-CO—NH—CH2-CH2-CO the linking group; NH the amine group present in a lysine residue of the carrier; Lys is a lysine amino acid residue and Pr the carrier protein. Also disclosed are isolated immunogens that include an immunogenic fragment of an influenza HA protein including the polybasic cleavage site, wherein the immunogenic fragment of the influenza HA protein has been modified to remove an N-terminal leader amino acid sequence and a C-terminal transmembrane domain. Also disclosed are methods producing an influenza vaccine specific for an identified influenza strain.
摘要(中):
公开了具有以下通式的免疫原性缀合物:M2e-Cys-S-CH2-C(O)-NH-CH2-CH2-C(O-NH-Lys-Pr),M2e是流感M2胞外域(M2e)肽 ; Cys是存在于M2e肽中的半胱氨酸氨基酸残基; S存在于半胱氨酸氨基酸残基中的硫; CH2-CO-NH-CH2-CH2-CO连接基团; NH存在于载体的赖氨酸残基中的胺基; Lys是赖氨酸氨基酸残基,Pr是载体蛋白。 还公开了分离的免疫原,其包括包括多碱性切割位点的流感HA蛋白的免疫原性片段,其中已经修饰了流感HA蛋白的免疫原性片段以除去N-末端前导氨基酸序列和C-末端跨膜结构域 。 还公开了产生针对所鉴定的流感病毒株特异的流感疫苗的方法。
公开/授权文献:
- US08658180B2 Vaccines against influenza virus 公开/授权日:2014-02-25
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K39/00 | 含有抗原或抗体的医药配制品 |
--------A61K39/385 | .半抗原或抗原,连结载体者 |