![REGULATION OF AUTOPHAGY PATHWAY PHOSPHORYLATION AND USES THEREOF](/abs-image/US/2010/04/08/US20100086541A1/abs.jpg.150x150.jpg)
基本信息:
- 专利标题: REGULATION OF AUTOPHAGY PATHWAY PHOSPHORYLATION AND USES THEREOF
- 专利标题(中):自动路径磷化氢的调节及其用途
- 申请号:US12505281 申请日:2009-07-17
- 公开(公告)号:US20100086541A1 公开(公告)日:2010-04-08
- 发明人: Chun WU , John A. Mountzouris , Bingren Hu , Chunli Liu
- 申请人: Chun WU , John A. Mountzouris , Bingren Hu , Chunli Liu
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/00 ; G01N33/53 ; A61P37/02
摘要:
The invention relates to polypeptides and proteins known to function in the autophagy pathway that have novel phosphorylation sites. The invention also relates to antibodies specific to these polypeptides and proteins that are phosphorylated or not phosphorylated at novel phosphorylated sites. The invention also relates to methods of producing these antibodies and use of these antibodies in the treatment of diseases related to autophagocytosis.
摘要(中):
本发明涉及已知具有新的磷酸化位点的自噬途径中已知功能的多肽和蛋白质。 本发明还涉及这些多肽的特异性抗体和在新的磷酸化位点被磷酸化或未磷酸化的蛋白质。 本发明还涉及产生这些抗体的方法和这些抗体在治疗与自噬作用相关的疾病中的用途。
公开/授权文献:
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K39/00 | 含有抗原或抗体的医药配制品 |
--------A61K39/395 | .抗体;免疫球蛋白;免疫血清,例如抗淋巴细胞血清 |