基本信息:
- 专利标题： MICROWAVE-ASSISTED PEPTIDE SYNTHESIS
- 专利标题（中）：微波辅助肽合成
- 申请号：US12549445 申请日：2009-08-28
- 公开(公告)号：US20100048865A1 公开(公告)日：2010-02-25
- 发明人： JONATHAN MCKINNON COLLINS , JOSEPH JOSHUA LAMBERT , MICHAEL JOHN COLLINS
- 申请人： JONATHAN MCKINNON COLLINS , JOSEPH JOSHUA LAMBERT , MICHAEL JOHN COLLINS
- 申请人地址： US NC MATTHEWS
- 专利权人： CEM CORPORATION
- 当前专利权人： CEM CORPORATION
- 当前专利权人地址： US NC MATTHEWS
- 主分类号： C07K1/04
- IPC分类号： C07K1/04 ; C07K1/06
摘要：
An instrument and method for accelerating the solid phase synthesis of peptides are disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, activating a second amino acid, coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.
摘要（中）：
公开了用于促进肽的固相合成的仪器和方法。 该方法包括以下步骤：通过将受保护的连接酸与去保护溶液混合在微波透明容器中，同时用微波照射混合的酸和溶液，活化第二个氨基酸，偶联 同时用微波在同一容器中照射组合物的第二个氨基酸，并且通过将相连的肽与裂解组合物在同一容器中混合同时用微波照射组合物来将固定相树脂切断连接的肽。
公开/授权文献:
- US08058393B2 Microwave-assisted peptide synthesis 公开/授权日：2011-11-15