发明申请
US20100009914A1 METHOD OF PROTECTING SENSITIVE MOLECULES FROM A PHOTO-POLYMERIZING ENVIRONMENT
审中-公开
基本信息:
- 专利标题： METHOD OF PROTECTING SENSITIVE MOLECULES FROM A PHOTO-POLYMERIZING ENVIRONMENT
- 专利标题（中）：从光聚合环境中保护敏感分子的方法
- 申请号：US12496680 申请日：2009-07-02
- 公开(公告)号：US20100009914A1 公开(公告)日：2010-01-14
- 发明人： Bianca Baroli , Robert Langer , Venkatram Prasad Shastri
- 申请人： Bianca Baroli , Robert Langer , Venkatram Prasad Shastri
- 申请人地址： US MA Cambridge
- 专利权人： Massachusetts Institute of Technology
- 当前专利权人： Massachusetts Institute of Technology
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61P43/00
摘要：
In one embodiment, the present invention is a substrate system of photo-polymerizable monomers and bioactive molecules admixed with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature. Upon polymerization, the monomers produce a cross-linked structure and the shielded bioactive molecules are protected from attack in the polymerized environment. In different aspects, the substrate system is used for drug delivery and tissue engineering and protection of enzymes, proteins and growth factors. In another embodiment, the present invention is a drug delivery system of photo-polymerizable monomers, drug molecules associated with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature, and a photopolymerizing means for polymerizing the monomers to produce a cross-linked structure including the drug molecules.
摘要（中）：
在一个实施方案中，本发明是可光聚合单体和生物活性分子的底物体系，其与单体混合，并通过在体温下经历固体凝胶转变的不溶性材料与单体屏蔽。 在聚合时，单体产生交联结构，并且保护的生物活性分子免受聚合环境的侵袭。 在不同方面，底物系统用于药物递送和组织工程和酶，蛋白质和生长因子的保护。 在另一个实施方案中，本发明是可光聚合单体的药物递送系统，与单体相关的药物分子，并通过在体温下经历固体凝胶转变的不溶性材料与单体屏蔽，以及用于聚合的光聚合装置 所述单体产生包括药物分子的交联结构。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K38/00 | 含肽的医药配制品 |
| --------A61K38/16 | .含有20个以上氨基酸的肽；胃泌激素；生长素抑制素；促黑激素；其衍生物 |