基本信息:
- 专利标题： TARGETING VECTOR-PHOSPHOLIPID CONJUGATES
- 专利标题（中）：靶向载体 - 磷脂结合体
- 申请号：US12257552 申请日：2008-10-24
- 公开(公告)号：US20090131636A1 公开(公告)日：2009-05-21
- 发明人： Philippe Bussat , Samir Cherkaoui , Hong (Helen) Fan , Bernard Lamy , Palaniappa Nanjappan , Radhakrishna Pillai , Sibylle Pochon , Bo Song , Rolf E. Swenson
- 申请人： Philippe Bussat , Samir Cherkaoui , Hong (Helen) Fan , Bernard Lamy , Palaniappa Nanjappan , Radhakrishna Pillai , Sibylle Pochon , Bo Song , Rolf E. Swenson
- 申请人地址： NL AMSTERDAM
- 专利权人： BRACCO INTERNATIONAL B.V.
- 当前专利权人： BRACCO INTERNATIONAL B.V.
- 当前专利权人地址： NL AMSTERDAM
- 主分类号： C07K1/00
- IPC分类号： C07K1/00
摘要：
Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.
摘要（中）：
提供具有高KDR结合亲和力的肽载体和用于制备此类载体的方法。 肽载体可以与磷脂结合并包含在超声造影剂组合物中。 这样的超声造影剂在治疗和诊断方法中是特别有用的，例如在成像含KDR组织和评估和治疗与肿瘤病症相关的血管生成过程中。 本发明还提供大规模生产高纯度二聚体和单体肽磷脂共轭物以及用于形成缀合物的前体材料的方法。 本发明还提供了大规模生产含有非常低水平的TFA的高纯度肽磷脂缀合物的方法。