基本信息:
- 专利标题： Optimized non-canonical zinc finger proteins
- 专利标题（中）：优化非规范锌指蛋白
- 申请号：US12286668 申请日：2008-10-01
- 公开(公告)号：US20090111188A1 公开(公告)日：2009-04-30
- 发明人： Qihua C. Cai , Vipula K. Shukla , Joseph F. Petolino , Lisa W. Baker , Robbi J. Garrison , Ryan C. Blue , Jon C. Mitchell , Nicole L. Arnold , Sarah E. Worden , Jeffrey Miller , Fyodor Urnov
- 申请人： Qihua C. Cai , Vipula K. Shukla , Joseph F. Petolino , Lisa W. Baker , Robbi J. Garrison , Ryan C. Blue , Jon C. Mitchell , Nicole L. Arnold , Sarah E. Worden , Jeffrey Miller , Fyodor Urnov
- 专利权人： Dow AgroSciences LLC,Sangamo BioSciences, Inc.
- 当前专利权人： Dow AgroSciences LLC,Sangamo BioSciences, Inc.
- 主分类号： C12N15/10
- IPC分类号： C12N15/10
摘要：
Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.
摘要（中）：
本文公开了包含CCHC锌配位残基的锌指。 还描述了锌指蛋白和包含这些CCHC锌指的融合蛋白以及编码这些蛋白的多核苷酸。 还描述了使用这些蛋白质进行基因编辑和基因调控的方法。
公开/授权文献:
- US08921112B2 Optimized non-canonical zinc finger proteins 公开/授权日：2014-12-30