发明申请
US20090048443A1 ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN
有权
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基本信息:
- 专利标题: ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN
- 专利标题(中):ARYL-和HETEROARYL取代的四氢喹啉和其用于阻断肾上腺素,多巴胺和丝氨酸蛋白酶的重复使用
- 申请号:US12252823 申请日:2008-10-16
- 公开(公告)号:US20090048443A1 公开(公告)日:2009-02-19
- 发明人: Bruce F. MOLINO , Shuang LIU , Peter R. GUZZO , James P. BECK
- 申请人: Bruce F. MOLINO , Shuang LIU , Peter R. GUZZO , James P. BECK
- 申请人地址: US VT Manchester Center
- 专利权人: AMR TECHNOLOGY, INC.
- 当前专利权人: AMR TECHNOLOGY, INC.
- 当前专利权人地址: US VT Manchester Center
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; C07D401/04 ; C07D413/04 ; C07D413/14 ; C07D417/04 ; C07D417/14
摘要:
The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3 -a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined below in R14; with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.
摘要(中):
本发明的化合物由式(I)中所示的化学结构表示:其中:指定为*的碳原子为R或S构型; 并且X是选自苯并呋喃基,苯并[b]噻吩基,苯并异噻唑基,苯并异恶唑基,吲唑基,吲哚基,异吲哚基,吲嗪基,苯并咪唑基,苯并恶唑基,苯并噻唑基,苯并三唑基,咪唑并[1,2-a ]吡啶基,吡唑并[1,5-a]吡啶基,[1,2,4]三唑并[4,3-a]吡啶基,噻吩并[2,3-b]吡啶基,噻吩并[3,2-b] 二氢苯并噻吩基,二氢苯并呋喃基,二氢苯并噻吩基,四氢萘基,喹啉基,异喹啉基,4H-喹啉基,9H-喹啉基,喹唑啉基,噌啉基,酞嗪基,喹喔啉基, 苯并[1,2,3]三嗪基,苯并[1,2,4]三嗪基,2H-色烯基,4H-色烯基和稠合的双环碳环或稠合双环杂环,其任选被如所定义的取代基(数目为1至4) 在R14以下 本文定义的R1,R2,R3,R4,R5,R6,R7,R8和R14。
公开/授权文献:
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D401/00 | 杂环化合物,含有两个或更多个杂环,以氮原子作为仅有的杂环原子,至少有1个环是仅含有1个氮原子的六元环 |
--------C07D401/14 | .含有3个或更多个杂环 |