基本信息:
- 专利标题： Modulators of cellular adhesion
- 申请号：US11978388 申请日：2007-10-29
- 公开(公告)号：US20080176896A1 公开(公告)日：2008-07-24
- 发明人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
- 申请人： Wang Shen , Kenneth Barr , Johan D. Oslob , Min Zhong
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61P37/00 ; C07D217/00
摘要：
The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
公开/授权文献:
- US07745460B2 Modulators of cellular adhesion 公开/授权日：2010-06-29
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/47 | ....喹啉；异喹啉 |