发明申请
US20070270391A1 2Alpha-Methyl and 2Beta-Methyl Analogs of 19,26,27-Trinor-(20S)-1Alpha-Hydroxyvitamin D3 and Their Uses
有权
基本信息:
- 专利标题： 2Alpha-Methyl and 2Beta-Methyl Analogs of 19,26,27-Trinor-(20S)-1Alpha-Hydroxyvitamin D3 and Their Uses
- 专利标题（中）：19,26,27-三硝基 - （20S）-1α-羟基维生素D 3及其用途的2α-甲基和2β-甲基类似物
- 申请号：US11775042 申请日：2007-07-09
- 公开(公告)号：US20070270391A1 公开(公告)日：2007-11-22
- 发明人： Hector DeLuca , Lori Plum , Pawel Grzywacz , Margaret Clagett-Dame
- 申请人： Hector DeLuca , Lori Plum , Pawel Grzywacz , Margaret Clagett-Dame
- 申请人地址： US WI Madison
- 专利权人： Wisconsin Alumni Research Foundation, a non-stock, non-profit Wisconsin corporation
- 当前专利权人： Wisconsin Alumni Research Foundation, a non-stock, non-profit Wisconsin corporation
- 当前专利权人地址： US WI Madison
- 主分类号： A61K31/593
- IPC分类号： A61K31/593 ; A61P43/00 ; C07C401/00
摘要：
This invention discloses 2α-methyl and 2β-methyl analogs of 19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. These compounds also have little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. These compounds may also be used for the treatment or prevention of obesity.
摘要（中）：
本发明公开了19,26,27-三硝基 - （20S）-1α-羟基维生素D 3 3的2α-甲基和2b-甲基类似物及其药物用途。 这些化合物在阻止未分化细胞的增殖并诱导其分化为单核细胞方面表现出显着的活性，从而证明其用作抗癌剂并用于治疗皮肤疾病如牛皮癣以及皮肤病症如皱纹，松弛皮肤， 皮肤干燥，皮脂分泌不足。 这些化合物也具有很少（如果有的话）钙活性，因此可用于治疗人体中的自身免疫性疾病或炎性疾病以及肾性骨营养不良。 这些化合物也可用于治疗或预防肥胖症。
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/593 | ..9,10开环胆甾烷，例如胆骨化醇、维生素D3 |