
基本信息:
- 专利标题: Antidiabetic bicyclic compounds
- 专利标题(中):抗糖尿病双环化合物
- 申请号:US11801841 申请日:2007-05-11
- 公开(公告)号:US20070265332A1 公开(公告)日:2007-11-15
- 发明人: Min Ge , Jiafang He , Fiona Wai Yu Lau , Gui-Bai Liang , Songnian Lin , Weiguo Liu , Shawn P. Walsh , Lihu Yang
- 申请人: Min Ge , Jiafang He , Fiona Wai Yu Lau , Gui-Bai Liang , Songnian Lin , Weiguo Liu , Shawn P. Walsh , Lihu Yang
- 主分类号: A61K31/381
- IPC分类号: A61K31/381 ; A61K31/343 ; A61K31/192 ; A61K31/195
摘要:
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要(中):
与环双环稠合的环状羧酸或羧酸衍生物(如酰胺)的三环化合物(包括其药学上可接受的盐和前体药物)是G-蛋白偶联受体40(GPR40)的激动剂,可用作治疗性化合物,特别是在 2型糖尿病的治疗,以及经常与该疾病相关的病症,包括肥胖症和脂质疾病,例如混合或糖尿病性血脂异常,高脂血症,高胆固醇血症和高甘油三酯血症。
公开/授权文献:
- US07442808B2 Antidiabetic bicyclic compounds 公开/授权日:2008-10-28
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/33 | .杂环化合物 |
----------A61K31/335 | ..仅有氧作为环杂原子的,例如制霉色基素 |
------------A61K31/381 | ...五元环的 |