基本信息:
- 专利标题： Process for producing 2'-(1h-tetrazol-5-yl)biphenyl-4-carbaldehyde
- 专利标题（中）：制备2' - （1h-四唑-5-基）联苯-4-甲醛的方法
- 申请号：US10595122 申请日：2004-09-01
- 公开(公告)号：US20070072923A1 公开(公告)日：2007-03-29
- 发明人： Nobushige Itaya , Kozo Matsui , Yutaka Ohtani , Hiroki Ueno , Toshikazu Kaneko
- 申请人： Nobushige Itaya , Kozo Matsui , Yutaka Ohtani , Hiroki Ueno , Toshikazu Kaneko
- 专利权人： SUMITOMO CHEMICAL COMPANY, LIMITED
- 当前专利权人： SUMITOMO CHEMICAL COMPANY, LIMITED
- 优先权： JP2003-313325 20030904
- 国际申请： PCT/JP04/13014 WO 20040901
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; C07D257/02
摘要：
The present invention provides a process for producing 2′-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde which comprises reacting 2′-cyanobiphenyl-4-carbaldehyde with a salt of azide; a process for producing a highly pure crystal of 2′-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde which comprises reacting 2′-cyanobiphenyl-4-carbaldehyde with a salt of azide, obtaining a crystal of 2′-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde, dissolving said crystal obtained and recrystallizing a highly pure crystal in tetrahydrofuran; and the like. According to the present process, 2′-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde which is useful as a synthetic intermediate of medicines can be produced in a short process at high yield and high purity.
摘要（中）：
本发明提供2' - （1H-四唑-5-基）联苯-4-甲醛的制备方法，其包括使2'-氰基联苯-4-甲醛与叠氮化物的盐反应; 2' - （1H-四唑-5-基）联苯-4-甲醛的高纯度晶体的制造方法，其包括使2'-氰基联苯-4-甲醛与叠氮化物的盐反应，得到2'- （1H-四唑-5-基）联苯-4-甲醛，将所得晶体溶解并将高纯度结晶重结晶于四氢呋喃中; 等等。 根据本发明，可以以高产率和高纯度的短时间制备可用作药物合成中间体的2' - （1H-四唑-5-基）联苯-4-甲醛。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/41 | ...有两个或两个以上环杂原子的五元环的，其中至少有1个氮原子，例如四唑 |