![Polyhydroxy phenols and their use in binding p-selectin](/abs-image/US/2006/12/07/US20060276545A1/abs.jpg.150x150.jpg)
基本信息:
- 专利标题: Polyhydroxy phenols and their use in binding p-selectin
- 专利标题(中):多羟基酚及其在结合p-选择素中的应用
- 申请号:US10558495 申请日:2004-05-07
- 公开(公告)号:US20060276545A1 公开(公告)日:2006-12-07
- 发明人: Erik Anna Biessen , Chantal Appeldoorn , Arnaud Bonnefoy , Theodorus Van Berkel , Johan Kuiper , Marc Hoylaerts
- 申请人: Erik Anna Biessen , Chantal Appeldoorn , Arnaud Bonnefoy , Theodorus Van Berkel , Johan Kuiper , Marc Hoylaerts
- 申请人地址: JP Tokyo
- 专利权人: YAMANOUCHI PHARMACEUTICAL CO., LTD.
- 当前专利权人: YAMANOUCHI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Tokyo
- 优先权: EP03012122.2 20030530; EP04075320.4 20040203; EP04075545.6 20040219; EP04075630.6 20040227
- 国际申请: PCT/EP04/04898 WO 20040507
- 主分类号: A61K31/198
- IPC分类号: A61K31/198 ; C07C237/02
摘要:
Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenols as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P-selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.
摘要(中):
提供作为酰基肽的非肽模拟物的多羟基酚,以及使用没食子酸提供部分制备没食子酸衍生物的方法以及含有多羟基苯酚的药物和营养组合物。 提供了使用多羟基酚作为药物,特别是制备用于预防,治疗或诊断其中涉及P-选择素的疾病或病症的药物。 相同的化合物也可以用作组合物中表达P-选择蛋白的细胞或组织的靶向工具,还包含载体中的活性化合物。
公开/授权文献:
- US07273951B2 Polyhydroxy phenols and their use in binding p-selectin 公开/授权日:2007-09-25
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/045 | .羟基化合物,例如醇类;其盐类,例如醇化物 |
----------A61K31/19 | ..羧酸;例如丙戊酸 |
------------A61K31/195 | ...含氨基的 |
--------------A61K31/197 | ....有与同一无环碳链相连的氨基和羧基的,例如γ氨基丁酸(GABA)、β丙氨酸、ε氨基己酸、泛酸 |
----------------A61K31/198 | .....α-氨基酸,例如丙氨酸、乙二胺四乙酸(EDTA) |