发明申请
US20060178401A1 Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof
审中-公开
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基本信息:
- 专利标题: Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof
- 专利标题(中):氨基苯氧基乙酰胺衍生物和含有它们的药物组合物
- 申请号:US11337664 申请日:2006-01-24
- 公开(公告)号:US20060178401A1 公开(公告)日:2006-08-10
- 发明人: Naohiro Takemoto , Hirokazu Annoura , Norihito Murayama
- 申请人: Naohiro Takemoto , Hirokazu Annoura , Norihito Murayama
- 专利权人: DAIICHI ASUBIO PHARMA CO., LTD.
- 当前专利权人: DAIICHI ASUBIO PHARMA CO., LTD.
- 优先权: JP2000-112100 20000413
- 主分类号: A61K31/454
- IPC分类号: A61K31/454 ; A61K31/445 ; C07D211/56 ; C07D401/02
摘要:
The present invention relates to an amiophenoxyacetamide derivative of the formula (I): wherein R1 to R4 are, independent from each other, a hydrogen atom or an optionally substituted alkyl group; E1 is —NR4—; and E2 is an oxygen atom or —NR10—; Q is the group —X—Y-Q′, wherein X and Y are connecting bonds or X is an alkylene or alkenylene group and Y is selected from a group comprising C═O, NHC(═O), and C(═O)NH, and Q′ is a hydrogen atom or a phenyl or pyridyl group which may be substituted; and pharmaceutically acceptable salts thereof. The present invention further relates to compositions comprising compounds of the formula (I) and methods of using said compounds for treating cerebral functional disorders and cerebral organic disorders.
摘要(中):
本发明涉及式(I)的氨基苯氧基乙酰胺衍生物:其中R 1至R 4彼此独立地为氢原子或任选取代的烷基 组; E 1是-NR 4 - ; 并且E 2是氧原子或-NR 10 - ; Q是-XY-Q'基团,其中X和Y是连接键或X是亚烷基或亚烯基,Y选自CO,NHC(-O)和C(-O)NH的基团,和 Q'是氢原子或可被取代的苯基或吡啶基; 及其药学上可接受的盐。 本发明还涉及包含式(I)化合物和使用所述化合物治疗脑功能障碍和脑部有机疾病的方法的组合物。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/33 | .杂环化合物 |
----------A61K31/335 | ..仅有氧作为环杂原子的,例如制霉色基素 |
------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的,例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
--------------A61K31/44 | ....非稠合的吡啶;其氢化的衍生物 |
----------------A61K31/4427 | .....含另外的杂环的 |
------------------A61K31/4523 | ......含有另外的杂环的 |
--------------------A61K31/454 | .......含有氮作为环杂原子的五元环的,如匹莫齐特、多潘立酮 |