![Fluorescent probe](/abs-image/US/2006/02/09/US20060030054A1/abs.jpg.150x150.jpg)
基本信息:
- 专利标题: Fluorescent probe
- 专利标题(中):荧光探针
- 申请号:US10519682 申请日:2003-07-07
- 公开(公告)号:US20060030054A1 公开(公告)日:2006-02-09
- 发明人: Tetsuo Nagano , Yasuteru Urano , Suguru Kenmoku , Kohjiro Kanda
- 申请人: Tetsuo Nagano , Yasuteru Urano , Suguru Kenmoku , Kohjiro Kanda
- 申请人地址: JP Tokyo
- 专利权人: Tetsuo Nagano,Daiichi Pure Chemicclas Co., LTD., of Tokyo, Japan
- 当前专利权人: Tetsuo Nagano,Daiichi Pure Chemicclas Co., LTD., of Tokyo, Japan
- 当前专利权人地址: JP Tokyo
- 优先权: JP2002-198197 20020708; JP2003-20295 20030129
- 国际申请: PCT/JP03/08585 WO 20030707
- 主分类号: G01N21/75
- IPC分类号: G01N21/75
摘要:
A fluorescent probe which is represented by the following formula (I): (wherein, R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species, or the like; R3 represents a monovalent substituent; R4 and R5 represent hydrogen atom or a halogen atom; R6 represents hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, provided that a combination of R1, R2, and R3 provides (1) substantially high electron density of the benzene ring to which said groups bind, so that the compound represented by the formula (I) is substantially no fluorescent before the trapping of proton, or the like, and (2) substantially reduced electron density of the benzene ring to which said groups bind, so that a compound after the trapping, which is derived from the compound represented by the formula (I) is substantially highly fluorescent after the trapping of proton or the like). A fluorescent probe having an excellent fluorescence property is provided.
摘要(中):
由下式(I)表示的荧光探针:(其中,R 1和R 2表示氢原子或用于捕获质子的取代基,金属离子 ,或活性氧类等; R 3表示一价取代基; R 4和R 5表示氢原子或卤素 原子; R 6表示氢原子,烷基羰基或烷基羰氧基甲基,条件是R 1,R 2和R 2的组合和 R 3提供(1)所述基团结合的苯环的基本上高的电子密度,使得由式(I)表示的化合物在质子捕获之前基本上不发荧光,或 和(2)所述基团结合的苯环的电子密度大大降低,从而得到由式(I)表示的化合物衍生的捕获后的化合物在其后基本上高度荧光 质子等的捕获)。 提供具有优异荧光性能的荧光探针。
公开/授权文献:
- US07524974B2 Fluorescent probe 公开/授权日:2009-04-28
IPC结构图谱:
G | 物理 |
--G01 | 测量;测试 |
----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
------G01N21/00 | 利用光学手段,即利用红外光、可见光或紫外光来测试或分析材料 |
--------G01N21/75 | .材料在其中经受化学反应的系统,测试反应的进行或结果 |