发明申请
US20040115180A1 Carrier chimeric proteins targeted carrier chimeric proteins and preparation thereof
审中-公开
基本信息:
- 专利标题： Carrier chimeric proteins targeted carrier chimeric proteins and preparation thereof
- 专利标题（中）：载体嵌合蛋白靶向载体嵌合蛋白及其制备
- 申请号：US10469613 申请日：2004-01-08
- 公开(公告)号：US20040115180A1 公开(公告)日：2004-06-17
- 发明人： Mustapha Abdelouahed
- 主分类号： A61K038/43
- IPC分类号： A61K038/43 ; C12N009/16
摘要：
A chimeric carrier protein having a multimerization domain and at least one drug attached thereto via a spacer is disclosed. The protein may be targeted by associating at least one amino acid sequence having an amino acid domain targeted to a specific site of action. In a further embodiment of the invention a nucleic acid molecule is provided which encodes the protein. Vectors containing the nucleic acid molecule and the host cells containing the vectors may also be provided. A method for producing the carrier chimeric protein on the targeted carrier chimeric protein is also disclosed.
摘要（中）：
公开了具有多聚化结构域和至少一种通过间隔基连接的药物的嵌合载体蛋白。 可以通过将至少一个具有靶向特定位点的氨基酸结构域的氨基酸序列缔合来靶向蛋白质。 在本发明的另一个实施方案中，提供了编码蛋白质的核酸分子。 还可以提供含有核酸分子和含有载体的宿主细胞的载体。 还公开了在靶载体嵌合蛋白上制备载体嵌合蛋白的方法。