基本信息:
- 专利标题： Gene delivery compositions and methods
- 申请号：US10092184 申请日：2002-03-05
- 公开(公告)号：US20020103156A1 公开(公告)日：2002-08-01
- 发明人： John H. Lawrence III , J. Kevin Donahue
- 申请人： Johns Hopkins University of Baltimore, Maryland
- 申请人地址： null
- 专利权人： Johns Hopkins University of Baltimore, Maryland
- 当前专利权人： Johns Hopkins University of Baltimore, Maryland
- 当前专利权人地址： null
- 主分类号： A61K048/00
- IPC分类号： A61K048/00 ; A61K038/17 ; A61K038/18 ; A61K038/20 ; A61K031/405 ; A61K031/417 ; A61K031/5575 ; A61K031/198
摘要：
The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers. Global delivery of nucleic acid to an intact heart has been achieved with as little as 2 minutes of intracoronary exposure to the administered nucleic acid.
公开/授权文献:
- US06855701B2 Gene delivery compositions and methods 公开/授权日：2005-02-15