基本信息:
- 专利标题： Beta-amino acid nitrile derivatives as cathepsin K inhibitors
- 专利标题（中）：β-氨基酸腈衍生物作为组织蛋白酶K抑制剂
- 申请号：US09872927 申请日：2001-06-01
- 公开(公告)号：US20020016361A1 公开(公告)日：2002-02-07
- 发明人： Tobias Gabriel , Michael Pech , Rosa Maria Rodriguez Sarmiento
- 优先权： EP00112577.2 20000614
- 主分类号： A61K031/357
- IPC分类号： A61K031/357 ; A61K031/277 ; A61K031/275 ; C07D317/44 ; C07C255/42
摘要：
The present invention relates to beta-amino acid nitrile derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are cysteine protease inhibitors useful for the treatment of diseases associated with cysteine proteases, such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.
摘要（中）：
本发明涉及β-氨基酸腈衍生物及其药学上可接受的盐和/或其药学上可接受的酯。 该化合物是半胱氨酸蛋白酶抑制剂，可用于治疗与半胱氨酸蛋白酶相关的疾病，例如骨质疏松症，骨关节炎，类风湿性关节炎，肿瘤转移，肾小球性肾炎，动脉粥样硬化，心肌梗塞，心绞痛，不稳定性心绞痛，中风，斑块破裂，短暂性脑缺血 攻击，黑斑病，外周动脉闭塞性疾病，血管成形术和支架置入后再狭窄，腹主动脉瘤形成，炎症，自身免疫性疾病，疟疾，眼底组织细胞病变和呼吸系统疾病。