A fluid control device is disclosed and comprises a piezoelectric actuator and a deformable substrate, the piezoelectric actuator is consist of a piezoelectric element attached on a surface of a vibration plate, when the piezoelectric element actuates by voltage, the piezoelectric element deforms and drives the vibration plate vibrates curvedly, the vibration plate comprises a protruding portion, which is attached on another surface of the vibration plate; and the deformable substrate is consist of a flexible board and a circulation board, which can be synchronously deformed into a synchronously deformed structure; wherein, the deformable substrate and the vibration plate of the piezoelectric actuator are correspondingly disposed and assembled with each other, and the deformable substrate protrudes in the direction which is away from the vibration plate, which defines a specific depth between the flexible board and the protruding portion of the vibration plate, which is disposed correspondingly with the protruding portion.